|
KMID : 0359919930120010027
|
|
Korean Journal of Nephrology
1993 Volume.12 No. 1 p.27 ~ p.35
|
|
|
Effect of Hemodialysis and Continuous Ambulatory Peritoneal Dialysis on Pharmacokinetics of Carumonam
|
|
임동석
신상구/조종태/한진석/김성권/이정상/이경훈/장인진
|
|
|
Abstract
|
|
|
To evaluate the influence of hemodialysis and continuous ambulatory peritoneal dialysis (CAPD0 on the elimination of carumonam, pharmacokinetic studies were performed in 14 CRF patients undergoing intermittent hemodialysis or CAPD after a single
intravenous dose of 1 g. Carumonam concentrations in biological fluid were measured by reverse phase high perfomance liquid chromatography.
In patients undergoing intermittent hemodialysis, carumonam plasma half-life of 14.36±5.18 hr was shortened to 2.25±0.54 hr during hemodialysis. Hemodialysis increased the total body clearance of carumonam from 14 0 to 82.0 ml/min, and the
amount
of
carumonam recovered into dialysate over 4 or 5 hr ranged from 363 to 895 mg (average: 520.6±163.9 mg). In patients undergoing CAPD, the volume of distribution and plasma half-life of carumonam were 0.26±0.091/kg and 10.5±4.36 hr, respectively.
The
time-averaged net clearance of peritoneal dialysis was negligible (3.6±1.7 ml/min) compared with hemodialysis clearance. Patient undergoing hemodialysis should receive a supplemental dose equal to half of their maintenance dose immediately after
each
dialysis session.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|